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The U.S. Government and Global Tuberculosis « » The Henry J. Kaiser Family Foundation

The U.S. Government and Global Tuberculosis


Tuberculosis (TB) is an airborne, infectious disease caused by bacteria which primarily affect the lungs.  While both preventable and curable, TB remains one of the world’s major causes of illness and death. Approximately one-third of the world’s population carry the TB bacteria, almost 9 million of whom develop “active” TB each year, which can be spread to others; (“latent TB” disease cannot be spread).1,2,3 In 1993, the World Health Organization (WHO) declared TB to be a global health emergency and in 2000, the United Nations Millennium Development Goals (MDGs) adopted by all nations included global TB targets to halt and reverse TB incidence, prevalence, and deaths by 2015. TB is found in every country in the world, but the majority of TB cases are concentrated in developing countries, particularly those in Asia and Africa (see Figure 1).1,2,3

The U.S. government’s involvement in global TB efforts was relatively limited until the late 1990s. Since that time, U.S. efforts to address TB have grown and funding has increased, and today, the U.S. is one of the largest donors to global TB control efforts. With the passage of the U.S. Leadership Against HIV/AIDS, Tuberculosis, and Malaria Act of 2003 (Leadership Act), which created the President’s Emergency Plan for AIDS Relief (PEPFAR), a heightened priority was given to  global TB efforts.4  PEPFAR’s 2008 reauthorization through the Lantos-Hyde U.S. Global Leadership Against HIV/AIDS, Tuberculosis, and Malaria Reauthorization Act (Lantos-Hyde) authorized specific funding levels and targets for TB.5 In May 2009, the Obama Administration launched the Global Health Initiative (GHI) as an effort to develop a comprehensive U.S. government strategy for global health and included TB as one of nine global health program areas.6

Figure 1: TB Incidence, Prevalence and Deaths by Region, 20121,7
WHO Region8
(# of HBCs)



(Excluding HIV related)

No. in thousands (%)

Per 100,000 Pop

No. in thousands

Per 100,000 Pop

No. in thousands

Per 100,000 Pop

Global Total (22)

8,600 (100%)






Africa (9)

2,300 (27%)






Americas (1)

280 (3%)






E. Mediterranean (2)

670 (8%)






Europe (1)

360 (4%)






South-East Asia (5)

3,400 (40%)






Western Pacific (4)

1,600 (19%)






* Represents WHO’s “best estimate”; for each indicator the WHO presents a range of values.

Current Global Snapshot

TB disproportionately affects people in resource-poor settings – more than 95% of TB cases and deaths occur in low- and middle-income countries, posing significant challenges to the livelihoods of individuals and developing economies as TB primarily affects people during their most productive years.1,2

  • TB Cases & Deaths:1 In 2012, an estimated 12.0 million people were living with (active) TB, including 8.6 million new cases, and there were an estimated 1.3 million TB deaths. Twenty-two countries are considered “high-burden countries (HBCs)”, accounting for more than 80% of new TB cases each year.
  • TB & HIV: TB and HIV are frequently referred to as co- or dual-epidemics due to their high rate of co-infection, and TB is a leading cause of death among people with HIV, especially in developing countries.9 In 2012, an estimated 1.1 million of the 8.6 million new TB cases were also HIV-positive; of the 1.3 million people who died from TB, an estimated 320,000 were HIV-positive.1
  • Drug-Resistant TB: Drug-resistant TB – both multidrug-resistant TB (MDR-TB), which fails to respond to standard first line drugs and, extensively drug-resistant TB (XDR-TB), which fails to respond to both first and second line drugs – has emerged as a major challenge to global TB control efforts.2,10  In 2012, there were an estimated 450,000 new cases of MDR-TB; XDR-TB has been reported in 92 countries and territories.2,10
  • Interventions: DOTS, “directly observed treatment, short-course”, is the internationally recommended strategy to control TB.  DOTS aims to decrease TB-related morbidity, prevent TB deaths, and decrease TB transmission and is comprised of 5 components: sustained political and financial commitment, quality diagnosis via sputum-smear microscopy, treatments taken under direct supervision, a regular and uninterrupted supply of drugs, and standardized data collection.

The U.S. Government Response


The U.S. Agency for International Development (USAID), the lead U.S. government agency on global TB control, began its TB control program in 1998.11

Passage of the Leadership Act in 2003 included TB under its umbrella, and authorized bilateral funding in “such sums as necessary” to address TB as well as funding for the Global Fund to Fight AIDS, Tuberculosis and Malaria (Global Fund).4 Created in 2001, the Global Fund is an independent, international financing institution that provides grants to countries to address TB (as well as HIV and malaria).

In 2004, USAID announced an expanded TB response plan which targeted 35 countries and outlined a specific set of goals.12 This plan was updated in 2009, expanding the number of target countries and re-aligning the U.S. approach in support of the international Stop TB Strategy and Global Plan to Stop TB, both of which were released in 2006.13,14,15

The passage of Lantos-Hyde in 2008 authorized specific funding levels (up to $4 billion over 5 years) and targets for U.S. TB control efforts.5 It also required the development of a five-year strategy for the U.S. government’s global TB effort.5

The GHI highlighted TB as one of nine program areas and includes specific targets designed around the TB objectives outlined by the five-year Lantos-Hyde TB strategy and the Global Plan to STOP TB including: contribute to the treatment of a minimum of 2.6 million new sputum smear positive TB cases and 57,200 multi-drug resistant (MDR) cases of TB, and contribute to a 50 percent reduction in TB deaths and disease burden relative to the 1990 baseline.16,17

Structure and Approach

U.S. Government Global Tuberculosis (TB) Program Countries, FY 2013

Figure 2: U.S. Government Global Tuberculosis (TB) Program Countries, FY 2013

The USG currently works with 27 countries in its efforts to address TB, including a majority of the 22 HBCs (see Figure 2).18,19 Programs are tailored to support specific country needs as outlined in a partner country’s national TB strategic plan.17

As the lead agency, USAID’s TB efforts are guided by the TB goals outlined in the GHI and by the Lantos-Hyde TB Strategy, which highlights four key interventions: accelerated detection and treatment of TB for all patients; scaled up prevention and treatment of MDR-TB; expanded coverage of interventions for TB-HIV co-infection in coordination with USG HIV efforts under PEPFAR; and improvements in the overall health system.17

Other departments and agencies involved in the USG’s international TB response include: the Office of the Global AIDS Coordinator (OGAC) at the State Department, which leads the USG’s efforts to address TB-HIV co-infection; the Centers for Disease Control and Prevention (CDC), which provides technical support on epidemiology and surveillance, laboratory strengthening, and clinical operations/operational research; and the National Institutes of Health (NIH), which conducts basic, applied, and clinical research for the development of new drugs, vaccines, and diagnostics.20 Additionally, an inter-agency, technical-level working group focused on international TB efforts operates under the Federal Tuberculosis Task Force.20

In addition to bilateral TB efforts, the USG also partners with international institutions such as the World Health Organization (WHO), and the Stop TB Partnership – an international network of public and private entities working to eliminate TB that was created in 1998 with the WHO serving as a lead agency and Secretariat.19 Additionally, the U.S. is the largest donor to the Global Drug Facility, a mechanism of the Stop TB Partnership that provides grants to countries for TB drugs, and the Global Fund which has committed approximately $4.7 billion in funding for TB programs.19,21

U.S. Government Funding22

Most U.S. government funding for TB is part of the “Global Health Programs” (GHP) account (formerly the Global Health and Child Survival account) at USAID with additional TB funding provided through the Economic Support Fund (ESF) account.

U.S. Global Health Funding: Bilateral Tuberculosis (TB), FY 2001 to FY 2015

Figure 3: U.S. Global Health Funding: Bilateral Tuberculosis (TB), FY 2001 to FY 2015

Congressional appropriations to USAID for TB increased from $64 million in FY 2001 to a high of $256 million in FY 2012.21 The FY 2015 budget request for TB includes $191 million through the GHP account, which would represent a decrease of $45 million (-19%) below FY 2014 (see Figure 3) and would be the lowest level of funding since FY 2009.21 Additional funding for TB through the ESF account in the FY 2015 budget request is not yet known (in prior years, it has ranged between $8 and $20 million).

All TB funding is counted as part of PEPFAR, which also includes funding for U.S. global HIV/AIDS efforts and U.S. contributions to the Global Fund. These amounts are now counted under the broader umbrella of the GHI, which brings together several different existing funding streams for global health.

Looking Ahead

The U.S. is one of the largest donors to TB control efforts and has highlighted TB as a key component of its global health investment. Key issues and challenges going forward include:
  • Implementing TB control programs in the context of weak health systems, limited laboratory capacity, treatment barriers and complications, and the emergence of drug-resistant TB;
  • Coordinating TB control efforts with other programmatic areas of the U.S. global health response, particularly HIV due to the problem of TB-HIV co-infection, but also maternal and child health and other key priorities;
  • Coordinating efforts with other donors, including the Global Fund, in order to maximize the impact of available resources, given the challenges that remain;
  • Funding uncertainties given the challenges of the current fiscal environment.
  1. WHO. Global Tuberculosis Control 2013; October 2013.

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  2. WHO. Tuberculosis, Fact sheet No. 104; October 2013.

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  3. WHO. Tuberculosis Global Facts: WHO Global Tuberculosis Report 2012; October 2013.

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  4. U.S. Congress. Public Law No: 108-25; May 27, 2003.

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  5. U.S. Congress. Public Law No: 110-293; July 30, 2008.

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  6. The White House, Office of the Press Secretary, Statement by the President on Global Health Initiative; May 5, 2009.

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  7. Kaiser Family Foundation Analysis.

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  8. WHO region definitions:

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  9. WHO. Frequently asked questions about TB and HIV;

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  10. WHO. Multidrug-resistant tuberculosis (MDR-TB) – fact sheet; October 2013.

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  11. USAID. Fast Facts, Tuberculosis; October 2010.

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  12. USAID. Expanded Response to Tuberculosis; September 2004.

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  13. USAID. Expanded Response to Tuberculosis; Updated January 2009.

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  14. WHO. The Stop TB Strategy; March 2006.

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  15. The Stop TB Partnership. The Global Plan to Stop TB (2006–2015); January 2006.

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  16. U.S. Government, United States Government Global Health Initiative Strategy Document; March 2011.

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  17. USAID, Lantos-Hyde United States Government Tuberculosis Strategy; March 2010.

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  18. USAID, Tuberculosis website,, accessed March 2014.

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  19. KFF analysis of data from U.S. Foreign Assistance website,, accessed February 2014.

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  20. USAID, Accelerating Impact: Expanding Access to Care –U.S. Government Report on International Foreign Assistance for TB FY 2011/2012; March 2013.

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  21. Global Fund. Grants Portfolio; accessed March 2014, available at:

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  22. KFF analysis of data from FY 2015 Budget Request; Agency Budgets and Congressional Budget Justifications; U.S. Foreign Assistance website,; and KFF personal communication with Office of Management and Budget.

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