In this article in “Policy Review,” a publication of Stanford University’s Hoover Institution, Mark Dybul, co-director of the Global Health Law Program and the inaugural global health fellow at the George W. Bush Institute; Peter Piot, director of the London School of Hygiene and Tropical Medicine; and Julio Frenk, dean of the Harvard School of Public Health, discuss the need for “a structural and philosophical shift” in the global health field, writing, “As we approach the post-[Millennium Development Goal] era, now is the time for a new framework to establish an accelerated trajectory to achieve a healthy world.” The authors recount the history of global health work in recent years and outline several “conceptual foundations of a new era in global health and development.” They conclude, “That is an audacious vision, but the recent history of global health and a long history of great human achievements teach us that what seems impossible can be done” (6/1).