In a PLOS Medicine essay, researchers from Sweden, South Africa, Denmark, the U.K., Jamaica, Ghana and Vietnam “present a range of reflections on the Global Burden of Disease 2010 estimates, highlighting their strengths as well as challenges for potential users,” the summary states. “The Institute for Health Metrics and Evaluation (IHME) and its partners recently completed what is probably the largest ever exercise undertaken in epidemiological modeling, the Global Burden of Disease 2010 (GBD-2010) estimates,” the authors write, adding, “However, it is important to realize that ‘estimates are estimates, and not measurements’; they may perform better in some respects than others.” They conclude, “While GBD-2010 is undoubtedly a massive achievement for global health, our discussion above also reveals continuing concerns. … Planners and policymakers, in particular, need to come to an understanding of how much reliance they should reasonably place on these estimates, especially in data-sparse countries” (Byass et al., 7/2).