“As researchers, clinicians, patients, funders, civil society, and public health practitioners engaged in research and development (R&D) and implementation of treatment and prevention programs, we have decided to join forces to create a coalition aimed at changing the future of Chagas disease,” a group called the Global Chagas Disease Coalition writes in the PLOS “Speaking of Medicine” blog. They call for improved access to treatment; an improved global Chagas disease R&D agenda; “prevention of different forms of transmission in endemic and non-endemic countries”; and increased public and policy awareness of the disease (10/31). In PLOS Neglected Tropical Diseases, Peter Hotez, co-editor in chief of the journal and dean of the National School of Tropical Medicine at Baylor College of Medicine, and colleagues write about the increasing number of Chagas cases in North America and call for improved surveillance data (10/31).