BBC News: Malaria vaccine: How good is good enough?
Seth Berkely, CEO of Gavi, the Vaccine Alliance, and Mark Dybul, executive director of the Global Fund to Fight AIDS, Tuberculosis and Malaria

“How effective does a vaccine have to be before it should be made available? … Such is the question World Health Organization (WHO) experts will now be preparing to ask themselves as they consider whether or not to recommend the world’s first malaria vaccine for use in affected countries in Africa. … The best way to get any clarity on these issues is to see how the vaccine performs in a real-life setting, in high and low transmission areas, with and without high coverage of other interventions. … Currently, several phase four trials have been proposed for Mosquirix, some of which aim to shed more light on its effectiveness … yet none of these studies are fully-funded. That has to change. … Given the vast scale of the number of people affected, we have a duty to fill these gaps in our knowledge” (7/23).