“A paper published in Nature [on Monday] sheds light on how a vaccine can turn the immune system against [HIV] and so offer protection from infection,” Nature News reports, noting “[t]he results are also being presented at the AIDS Vaccine 2012 conference in Boston, Massachusetts, this week” (Callaway, 9/10). Previous results from a trial called RV144 showed that two vaccines, Sanofi’s Alvac and VaxGen’s Aidsvax, reduced the risk of HIV infection by 31 percent over three years when used together, compared with people who received a placebo, according to Bloomberg (Bennett, 9/10). Last year, researchers showed “that those who responded to the vaccine and fended off HIV tended to produce antibodies against a specific part of the virus’s protein shell called the V1/V2 loop,” Nature News writes, adding, “The study published [Monday] goes a stage further, showing that the people who were vaccinated yet still contracted HIV had been infected by viruses that had mutations in the V2 portion.”
“The leading candidate to become the world’s first vaccine against dengue fever was only 30 percent effective in its first large clinical trial, dealing at least a temporary setback to efforts to control a disease that threatens half the world’s population,” the New York Times reports. “Still, the study marked a milestone in the 70-year quest to develop such a vaccine, demonstrating that a safe and effective inoculation against dengue is feasible, researchers reported in a paper published online Monday in the Lancet,” the newspaper adds (Pollack, 9/10). “Tested among just over 4,000 children in rural Thailand who were badly exposed to the mosquito-borne fever, the vaccine had no side effects but only worked against three out of the four dengue strains,” Agence France-Presse writes (9/10).
Most Asian Countries Fail To Include Rotavirus Vaccine In National Immunization Programs Citing Cost As Barrier
“Most countries in Asia have yet to make the rotavirus vaccine part of their national immunization program (NIP), despite a World Health Organization (WHO) recommendation to do so,” IRIN reports. “Worldwide, rotavirus accounts for 37 percent of all diarrhea deaths in children under five with 95 percent of those deaths occurring in developing countries,” the news service states, noting, “There are no antibiotics or any other drug to fight the infection and since 2009 WHO has recommended the global use of the rotavirus vaccine.” Forty-one countries worldwide include rotavirus vaccine in their NIPs, but “only two countries in Asia — Philippines and Thailand — are vaccinating (or are about to) children against rotavirus,” according to IRIN. An email to IRIN from WHO’s Manila office stated, “Price continues to be an important barrier to introducing rotavirus vaccine,” the news service notes (9/7).
“With a completed trial in Thailand that offered evidence a vaccine could be developed to protect people from HIV, emerging science identifying antibodies against HIV, and a current trial testing a novel vaccine combination against the virus potentially producing more information in the next year, this is an exciting time to hold a conference, organizers of AIDS Vaccine 2012 say,” the Center for Global Health Policy’s “Science Speaks” blog reports. “AIDS Vaccine 2012, which begins this Sunday and runs through Wednesday in Boston, will bring together about 1,000 participants, 120 scientists and scholars, discussion of 440 research studies, and speakers that, along with Massachusetts Governor Deval Patrick and National Institute of Allergy and Infectious Diseases Director Anthony Fauci, will include researchers known for work in HIV treatment as prevention of transmission, pre-exposure antiretroviral treatment as prevention (PrEP — or pre-exposure prophylaxis), and topical microbicides,” the blog notes (Barton, 9/6).
“The government of Uganda has launched a vaccination campaign against cervical cancer — the most common type of cancer among Ugandan women — but there are already fears a nationwide rollout might be jeopardized by lack of funds,” IRIN reports. “‘We have begun the pilot vaccination exercise [targeting] cervical cancer. The exercise will continue for the next two years in the selected districts before we roll it [out] countrywide,’ Health Minister Christine Ondoa said,” the news service writes, noting, “An estimated 460,000 doses of Gardasil, the vaccine against the human papillomavirus (HPV), will be used.” “The campaign is being supported by Merck, the company that manufactures Gardasil,” the news service continues, adding, “But Asuman Lukwago, a senior ministry health official, told IRIN, ‘We have a challenge [getting the] money to complete this program and roll it out throughout the country'” (9/6).
Pakistan Official Says Progress Made In Vaccinating Thousands Of Children Against Polio In Tribal Area
“Pakistan Tuesday claimed progress in vaccinating thousands of children against polio in a tribal area bordering Afghanistan which had been inaccessible due to unrest for about three years,” Agence France-Presse reports. “‘Our target was to vaccinate up to 25,000 children in Bara and some 32,000 children in Tirah valley in Khyber and 70 percent success has been achieved,’ top social welfare officer for tribal areas Aftab Durrani told AFP,” the news service writes.
“Cholera vaccine gives indirect protection to unvaccinated people in communities where a substantial fraction of the population gets the vaccine,” according to a study from the island of Zanzibar in East Africa, published in the Lancet on Tuesday, NPR’s “Shots” blog reports. “The effect is called ‘herd immunity,'” the blog notes. According to “Shots,” “half the people in six rural and urban areas received two doses of oral cholera vaccine,” and “[f]or those who got it, the vaccine was 79 percent protective against the disease” while “their neighbors who didn’t get vaccinated had almost as much protection.”
VOA News reports on global efforts to eradicate polio, writing, “Experts say with India now polio-free and the total number of cases at the lowest level ever, this is an opportunity to change history and eradicate the disease entirely.” “The oral polio vaccine has cut the number of polio cases worldwide by 99 percent since 1988,” but, “[f]or the past 10 years, … eliminating that last percent has remained a challenge,” the news service continues. “The three countries where polio is still endemic — Nigeria, Pakistan, and Afghanistan — are conducting aggressive immunization campaigns to vaccinate more children against the disease,” VOA notes.
U.N. Secretary-General Ban Ki-moon “warned on Friday that Haiti was struggling to cope with a cholera epidemic that has killed thousands and deteriorating conditions in tent camps as aid groups withdraw from the impoverished country due to a lack of funding,” Reuters reports. “In a report to the U.N. Security Council, Ban said there had been an increase in the number of cholera cases since the rainy season began in early March and the World Health Organization had projected there could be up to 112,000 cases during 2012,” the news service writes.
As the BRIC countries — Brazil, Russia, India, and China — invest more in innovations in health technologies and other areas, “many are looking to these countries to correct the global health research and development (R&D) imbalance that leaves the poor without needed products such as an improved tuberculosis (TB) vaccine or tests to help diagnose patients in remote rural settings,” David de Ferranti, president of Results for Development Institute (R4D), writes in the Huffington Post Blog. Writing that “India, which has already played such an important role in manufacturing affordable antiretroviral drugs, vaccines, and other essential health commodities for developing countries,” de Ferranti asks whether India “is … ready to play a leading role in health R&D?”