Federal officials have asked the National Science Advisory Board for Biosecurity (NSABB) “to review the state of the science looking at human transmission of deadly bird flu, says panel chief Paul Keim of Northern Arizona University,” USA Today reports. “In December, the NSABB asked the journals, Science and Nature, to withhold details of studies that showed how to make the flu strain transmissible between ferrets, the closest mammal model for human-to-human transmission of the bug,” the newspaper notes. “‘We are now involved in a broader review,’ Keim says. … ‘This research is valuable, but saying this is just “basic” research ignores that influenza is a very special pathogen,’ Keim adds,” according to the newspaper (Vergano, 1/10).
Pneumonia & Flu
“An international debate over whether to censor new research on bird flu may soon prove academic, as other laboratories close in on similar findings showing how one of the most deadly viruses could mutate to be transmitted from one person to another,” Reuters reports. Last year, two teams of researchers reported study results “that showed how the H5N1 [bird flu] virus can be transmitted through airborne droplets between ferrets, a model for studying influenza in humans,” and the findings prompted the U.S. National Science Advisory Board for Biosecurity (NSABB) in December to advise “two leading journals, Nature and Science, to withhold details of the research for fear it could be used by bioterrorists,” the news service writes.
In this Huffington Post “Impact” blog post, Karl Hofmann, president and CEO of PSI, outlines 10 “milestones for the global health community” that occurred in 2011. Among the achievements, Hofmann says governments avoided making major cuts to foreign aid budgets despite a global economic downturn; studies supported “treatment as prevention” as an HIV prevention strategy; the number of malaria cases and deaths worldwide continued to decline; research showed a promising vaccine candidate to prevent malaria among children; and more women gained access to long-acting, reversible contraceptives. Hofmann also lists advances in social franchising; maternal health; lesbian, gay, bisexual and transgender rights; pneumonia prevention and treatment; and sanitation, hygiene and access to clean water (12/29).
“The World Health Organization issued a stern warning on Friday to scientists who have engineered a highly pathogenic form of the deadly H5N1 bird flu virus, saying their work carries significant risks and must be tightly controlled,” Reuters reports (Kelland, 12/30). The agency “warned … that while such studies were important, they could have deadly consequences,” the New York Times writes (McNeil/Grady, 1/2).
The PBS NewsHour blog “The Rundown” features excerpts from interviews with three experts discussing the recent debate over research conducted on the H5N1 bird flu virus. “What began as a question on whether scientific journals should publish the complete research has grown into an argument on whether to conduct these studies, and others like them, at all,” according to the blog, which features quotes from Richard Ebright, a molecular biologist at Rutgers; Vincent Racaniello, a microbiologist at Columbia; and Carl Zimmer, a science journalist and author (Pelcyger, 1/30).
“The World Health Organization says it will take a role in helping sort through an international scientific controversy over two bird flu studies that the U.S. government deemed too dangerous to publish in full,” the Canadian Press/Winnipeg Free Press reports. Keiji Fukuda, the WHO’s assistant director-general for health security and environment, on Sunday in an interview with the Canadian Press “said the agency will pull together international talks aimed at fleshing out the issues that need to be addressed and then work to resolve them.” On the advice of the National Science Advisory Board on Biosecurity (NSABB), the journals Science and Nature “have grudgingly agreed to abbreviate the papers, leaving out the details of how the work was done,” according to the news service.
The head of the NIH National Institute of Allergy and Infectious Diseases (NIAID), which funded “two projects that created a highly pathogenic [H5N1] flu virus mutation, has welcomed a two-month moratorium on further research while defending the value and safety of the experiments,” the Financial Times reports. NIAID Director Anthony Fauci “told the FT it was ‘right to get off the unnecessary fast track’ of a debate ‘played out in sound bites,’ and instead hold a serious international debate to determine future publication and practice in the field,” according to the newspaper (Jack, 1/22). “In a letter published in the journals Nature and Science on Friday, 39 scientists defended the research as crucial to public health efforts, including surveillance programs to detect when the H5N1 influenza virus might mutate and spark a pandemic,” Reuters writes, adding, “But they are bowing to fear that has become widespread since media reports discussed the studies in December that the engineered viruses ‘may escape from the laboratories’ … or possibly be used to create a bioterror weapon” (Begley, 1/20).
The WHO is expected to hold a meeting in February to discuss controversy over recent research on the H5N1 bird flu virus, after the U.S. National Scientific Advisory Board for Biosecurity (NSABB) in December advised the journals Science and Nature to withhold publishing two teams’ research on the virus for fear the information could “fall into the wrong hands,” a commentary in the Economist’s “Babbage” blog states. “In a statement sent to Science, the WHO says that research” into bird flu genetics is “an important tool for global surveillance efforts,” the commentary says.
Global Health Frontline News (GHFN) reports on efforts to produce and provide clean cookstoves to people in Tanzania. The WHO estimates that indoor air pollution caused by smoke from cooking fires contributes to two million premature deaths annually, more than are caused by tuberculosis or malaria, according to GHFN. The piece includes comments from Radha Muthiah, executive director of the Global Alliance for Clean Cookstoves, and Everline Kihulla, who works for the Tanzanian clean cookstove manufacturer TaTedo (Striker, January 2012).
In this Journal Sentinel Online opinion piece, Thomas Inglesby, chief executive officer and director of the Center for Biosecurity of UPMC in Baltimore; Anita Cicero, chief operating officer and deputy director of the center; and D.A. Henderson, a distinguished scholar at the center, comment on a recent announcement by scientists that they have genetically modified a strain of H5N1 bird flu that is “capable of spreading through the air between ferrets that were physically separated from each other,” indicating “it would be readily transmissible by air between humans.” They write, “We believe the benefits of [purposefully engineer(ing) avian flu strains to become highly transmissible in humans] do not outweigh the risks.”