“Preventable childhood deaths caused by illnesses such as pneumonia and diarrhea can be nearly eliminated in 10 years,” researchers from the Johns Hopkins Bloomberg School of Public Health and the National Institutes of Health write in a new commentary featured in the June issue of the Journal of the American Medical Association,” a Johns Hopkins press release reports. In the commentary, “researchers outline a strategy and benchmarks for curbing childhood preventable deaths and recommend a new common vision for a global commitment to end all preventable child deaths,” the press release notes (6/14).
Pneumonia & Flu
The New York Times examines several studies published in the journals Nature and Science looking at how the H5N1 bird flu virus could mutate to become more virulent among humans and outlines the history of controversy surrounding the studies. “While scientists have offered two possible ways in which H5N1 might become a human flu, they’re almost certainly not the only two,” the newspaper writes, adding, “There is no checklist of mutations that any bird flu must acquire to start infecting humans.” According to the newspaper, “Anthony S. Fauci, director of the National Institute of Allergy and Infectious Diseases, hopes scientists will be able to amass a longer list of potential mutations, and even find a common denominator in how they alter H5N1,” which might make it “possible to monitor emerging strains for signs that they are about to cross over into humans” (Zimmer, 6/25).
With Lessons Learned From Smallpox Eradication Efforts, Investment In Vaccines, Goal Of Ending Preventable Child Deaths Achievable
In this Baltimore Sun opinion piece, Orin Levine, executive director of the International Vaccine Access Center (IVAC) at the Johns Hopkins Bloomberg School of Public Health, and Myron Levine, the Grollman Distinguished Professor and director of the Center for Vaccine Development at the University of Maryland School of Medicine, discuss the successful eradication of smallpox last century and write that “the same can now be done for diarrhea and pneumonia.” They continue, “Eradicating smallpox taught us new ways to gather disease data, empower local leaders, create incentive programs, set up delivery chains and drive innovation,” but “the most important lesson was not to fear big, ambitious global health goals.”
The WHO on Thursday “announced the deaths of two men from H5N1 avian influenza, one from Egypt and another from China whose death was reported earlier in the media,” CIDRAP News reports. Both men are suspected to have contracted the virus from avian sources, although an investigation into the man from China’s exposure to the virus is ongoing, according to news service. “The two infections and deaths push the WHO global H5N1 count to 576 cases and 339 deaths. According to WHO records, the number of H5N1 cases and deaths reported in 2011 so far are modestly higher than 2010 (60 cases versus 48, and 33 deaths versus 24),” CIDRAP writes (Schnirring, 1/5).
Author Laurie Garrett, senior fellow for global health at the Council on Foreign Relations, writes in this Foreign Policy opinion piece that the announcement that researchers from Norway and the U.S. have developed a supercontagious variety of bird flu “has highlighted a dilemma: How do you balance the universal mandate for scientific openness against the fear that terrorists or rogue states might follow the researchers’ work — using it as catastrophic cookbooks for global influenza contagion?” She continues, “Along with several older studies that are now garnering fresh attention, [the research] has revealed that the political world is completely unprepared for the synthetic-biology revolution” and notes “there are no consistent, internationally agreed-upon regulations governing synthetic biology, the extraordinarily popular and fruitful 21st-century field of genetic manipulation of microorganisms.”
Research into transmissible bird flu strains remains “urgent” despite flu investigators’ recent declaration of a “60-day moratorium on avian flu transmission because of the current controversy,” Yoshihiro Kawaoka of Tokyo University and the University of Wisconsin-Madison, “a lead researcher on one of two recent studies showing how H5N1 can be transmitted through airborne droplets” among ferrets, writes in a commentary published Wednesday in the journal Nature, Reuters reports. In December, the U.S. National Science Advisory Board for Biosecurity “asked two leading journals, Nature and Science, to withhold details of both studies for fear it could be used by bioterrorists,” the news agency notes.
In this post in PSI’s “Healthy Lives” blog, “PSI’s Nutrition Research Adviser Dr. Abel Irena talks with Saul Morris, senior program officer at the Bill & Melinda Gates Foundation, about progress that has been made in child health.” Morris addresses treatment for pneumonia, diarrhea, and malaria among children, delivery and access to integrated health systems, the Gates Foundation’s focus on newborn health, and the most effective steps to take to reach the fourth Millennium Development Goal to reduce child mortality by 2015 (5/24).
“The World Health Organization (WHO) hopes to hold a meeting late this fall to discuss ‘dual-use’ research issues raised in the controversy over publication of two studies involving lab-modified H5N1 viruses with increased transmissibility, a WHO official said,” CIDRAP News reports. “The WHO hosted a closed meeting of disease experts and government officials Feb 16 and 17 to discuss the two H5N1 studies,” CIDRAP notes, adding that “the WHO [on Wednesday] released a brief statement about its activities related to the H5N1 research controversy since the February meeting in Geneva.” Keiji Fukuda, the WHO’s assistant director-general for health security and environment, said, “We hope to hold a second meeting to discuss the broader concerns related to potential dual [use] research in the late fall, if resources are available,” the news service notes.
In a letter (.pdf) dated April 25, Amy Patterson, associate director for science policy in the office of the director of the National Institutes of Health, “has refuted criticism of the way a meeting held to allow a biosecurity advisory group to review controversial bird flu studies was handled,” denying “the agenda was crafted to achieve a predetermined outcome,” the Canadian Press/Winnipeg Free Press writes. Patterson was “responding to a harsh critique of the meeting from Michael Osterholm, a member of the U.S. National Science Advisory Board for Biosecurity [NSABB],” who, in a letter (.doc) to Patterson dated April 12, criticized “the agenda and speakers list” of the March 29-30 meeting, the news service writes (Branswell, 5/4).
“Pakistan is set to become the first country in south Asia to introduce the pneumococcal vaccine to protect children against pneumonia, one of the biggest killers of children under five in the developing world,” the Guardian reports, noting, “The program is due to be announced by the country’s prime minister, Raja Pervaiz Ashraf, on Tuesday, signaling clear political commitment from the Pakistani government in rolling out the vaccine.” The country’s expanded program on immunization (EPI) is introducing the vaccine in conjunction with the GAVI Alliance, UNICEF, and WHO, the newspaper adds. “In Pakistan, more than 423,000 children die before reaching their fifth birthday, and almost one in five of these deaths is due to pneumonia,” according to the Guardian, which notes, “The new pneumococcal vaccine is expected to prevent a significant proportion of pneumonia cases, and has the potential to save tens of thousands of lives” (Tran, 10/9).