In this Journal Sentinel Online opinion piece, Thomas Inglesby, chief executive officer and director of the Center for Biosecurity of UPMC in Baltimore; Anita Cicero, chief operating officer and deputy director of the center; and D.A. Henderson, a distinguished scholar at the center, comment on a recent announcement by scientists that they have genetically modified a strain of H5N1 bird flu that is “capable of spreading through the air between ferrets that were physically separated from each other,” indicating “it would be readily transmissible by air between humans.” They write, “We believe the benefits of [purposefully engineer(ing) avian flu strains to become highly transmissible in humans] do not outweigh the risks.”
Pneumonia & Flu
The WHO on Thursday “announced the deaths of two men from H5N1 avian influenza, one from Egypt and another from China whose death was reported earlier in the media,” CIDRAP News reports. Both men are suspected to have contracted the virus from avian sources, although an investigation into the man from China’s exposure to the virus is ongoing, according to news service. “The two infections and deaths push the WHO global H5N1 count to 576 cases and 339 deaths. According to WHO records, the number of H5N1 cases and deaths reported in 2011 so far are modestly higher than 2010 (60 cases versus 48, and 33 deaths versus 24),” CIDRAP writes (Schnirring, 1/5).
Author Laurie Garrett, senior fellow for global health at the Council on Foreign Relations, writes in this Foreign Policy opinion piece that the announcement that researchers from Norway and the U.S. have developed a supercontagious variety of bird flu “has highlighted a dilemma: How do you balance the universal mandate for scientific openness against the fear that terrorists or rogue states might follow the researchers’ work — using it as catastrophic cookbooks for global influenza contagion?” She continues, “Along with several older studies that are now garnering fresh attention, [the research] has revealed that the political world is completely unprepared for the synthetic-biology revolution” and notes “there are no consistent, internationally agreed-upon regulations governing synthetic biology, the extraordinarily popular and fruitful 21st-century field of genetic manipulation of microorganisms.”
Research into transmissible bird flu strains remains “urgent” despite flu investigators’ recent declaration of a “60-day moratorium on avian flu transmission because of the current controversy,” Yoshihiro Kawaoka of Tokyo University and the University of Wisconsin-Madison, “a lead researcher on one of two recent studies showing how H5N1 can be transmitted through airborne droplets” among ferrets, writes in a commentary published Wednesday in the journal Nature, Reuters reports. In December, the U.S. National Science Advisory Board for Biosecurity “asked two leading journals, Nature and Science, to withhold details of both studies for fear it could be used by bioterrorists,” the news agency notes.
NIH Official Discusses Reaction To Bird Flu Studies, Development Of Publishing Mechanism In Nature Interview
Nature interviews Amy Patterson, director of the National Institutes of Health (NIH) Office of Science Policy, which administers the National Science Advisory Board for Biosecurity (NSABB), about the board’s decision in December to advise against full publication of “two papers on avian flu (H5N1) [that] could pose a biosecurity risk if published in their entirety.” Patterson discusses the efforts of the board and the “international flu community” to “develop a mechanism by which important details from the papers could be withheld from the general public while remaining accessible to public health officials and researchers studying the virus,” Nature writes (Ledford, 1/11).
In this Huffington Post opinion piece, Leslie Gerwin, associate director of law and public affairs at Princeton University, reflects on the recent controversy over whether to research and publish data about potentially dangerous strains of the H5N1 bird flu virus, writing, “I am disturbed that so much coverage of this dispute — so deserving of sober consideration — is fixated on fear mongering.” She notes, “Those opposing research or publication … predict that publishing results will lead to abuse or misuse by terrorists looking to create a biological weapon. … Those favoring continuation of the project warn of ‘censorship,’ a constitutional no-no particularly when involving the ‘suppression’ of science.”
Bird flu experts are scheduled to begin a two-day meeting at the WHO in Geneva on Thursday “to try to settle an unprecedented row over a call to [censor] publication of two scientific studies which detail how to mutate H5N1 bird flu viruses into a form that could cause a deadly human pandemic,” Reuters reports in an article describing the debate in detail. “But experts say whatever the outcome, no amount of censorship, global regulation or shutting down of research projects could stop rogue scientists getting the tools to create and release a pandemic H5N1 virus if they were intent on evil,” the news service adds.
In December 2011, the U.S. National Science Advisory Board for Biosecurity (NSABB) advised that two research teams that had genetically altered the H5N1 virus to be easily transmissible among ferrets redact some of the research details before publishing in the journals Science and Nature. The board’s primary concern was that the altered virus could possibly be used as a bioweapon. Scientists in January voluntarily suspended bird flu research for 60 days, and the WHO is expected to hold a summit later this month to discuss the issue. The following are summaries of two opinion pieces on the topic.
“There have been 1,623 cases of all strains of flu in Mexico recorded so far for January, 90 percent of them H1N1 [swine flu],” compared to “about 1,000 flu cases in Mexico during all of last year,” of which roughly 250 cases were swine flu, Health Secretary Salomon Chertorivski Woldenberg told reporters on Tuesday, the Associated Press reports. The news service notes, “Despite the spike, the number of cases is well within a normal flu season for Mexico, which can see from 5,000 to 11,000 incidents of all strains,” Woldenberg said. “The low appearance of the H1N1 virus the past two years is one reason it’s drawing so much media attention in Mexico,” the AP writes, adding, “Public nervousness about H1N1 has been high since the first outbreak in spring 2009, when the virus initially appeared to have a high mortality rate and Mexican authorities closed restaurants, schools, museums, libraries, and theaters to stop its spread” (2/1).
WHO Meeting Decides To Extend Moratorium On Bird Flu Research, Delay Full Publication Of Two Studies Detailing Lab-Modified Strains
A group of 22 public health and influenza experts reached a consensus on Friday at a WHO-convened meeting regarding the work of two research teams that created genetically altered strains of the H5N1 bird flu virus that are easily transmissible among ferrets, a laboratory model for humans, a WHO press release reports (2/17). “In December, the [U.S. National Science Advisory Board for Biosecurity] asked two leading scientific journals, Nature and Science, to withhold details of the research for fear it could be used by bioterrorists,” Reuters writes, adding that on January 20, flu researchers also imposed a 60-day moratorium on continuing research using highly pathogenic strains (Nebehay/Kelland, 2/17). At the meeting, the group agreed to “extending the temporary moratorium on research with new laboratory-modified H5N1 viruses and recogni[zed] that research on naturally occurring H5N1 influenza virus must continue in order to protect public health,” the press release states, adding that they “also came to a consensus that delayed publication of the entire manuscripts would have more public health benefit than urgently partially publishing” (2/17).