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Clinical Trial Results Signal 'Promise, Unresolved Challenges' In Finding Effective Dengue Vaccine

The first-ever results from a dengue virus vaccine clinical trial aimed at showing effectiveness “provide signals rather than definitive answers, and a mixture of both promise and unresolved challenges,” Orin Levine, executive director of the International Vaccine Access Center, and Ciro de Quadros, executive vice president of the Sabin Vaccine Institute, write in the Huffington Post “Impact” blog. “To date, these represent the most promising indications that a safe, effective vaccine to prevent dengue is technically feasible,” they continue, adding, “At the same time, the results on protection were inconclusive, somewhat inconsistent with the measured immune responses and uneven across the four strains included in the vaccine.”

Leading Dengue Fever Vaccine Candidate 30% Effective In First Large Clinical Trial

“The leading candidate to become the world’s first vaccine against dengue fever was only 30 percent effective in its first large clinical trial, dealing at least a temporary setback to efforts to control a disease that threatens half the world’s population,” the New York Times reports. “Still, the study marked a milestone in the 70-year quest to develop such a vaccine, demonstrating that a safe and effective inoculation against dengue is feasible, researchers reported in a paper published online Monday in the Lancet,” the newspaper adds (Pollack, 9/10). “Tested among just over 4,000 children in rural Thailand who were badly exposed to the mosquito-borne fever, the vaccine had no side effects but only worked against three out of the four dengue strains,” Agence France-Presse writes (9/10).

WHO Releases Dengue Strategy Report, Sets Goal Of Cutting Related Deaths In Half By 2020

“Saying dengue virus infections and deaths have mushroomed in recent years, the World Health Organization (WHO) recently released a strategy report that sets a goal of cutting deaths in half and reducing cases by 25 percent over the next eight years,” CIDRAP reports. “The report, titled ‘Global Strategy for Dengue Prevention and Control,’ also sets a goal of estimating the true burden of dengue disease by 2015 — signaling how little is known about the global impact of the mosquito-borne illness,” the news service writes. “In general, the report says that the tools already exist to make a big dent in the dengue problem, but that better tools, particularly in the diagnostic realm, are urgently needed,” CIDRAP notes, adding, “Currently there is no licensed vaccine or specific treatment for dengue fever or its more serious complication, dengue hemorrhagic fever” (Roos, 9/4).

Dengue Fever Costs Puerto Rico Nearly $38M A Year, Study Shows

“The costs of treating and coping with dengue fever in Puerto Rico total nearly $38 million a year, a new study,” published Wednesday in the American Journal of Tropical Medicine and Hygiene, finds, according to U.S. News & World Report. “It also said that every $1 spent on surveillance and prevention of the mosquito-borne disease could save $5 in illness-related costs,” the news service reports (5/2). “A team of researchers from Brandeis University says households in the U.S. territory pay almost half of that cost, with the government and insurance companies splitting the rest,” the Associated Press/Seattle Times notes (5/2).

Number Of Recorded Dengue Cases Up 36% Over Last Year In Costa Rica

“A total of 8,480 people have been affected by dengue fever in Costa Rica” so far this year, representing an increase of 36 percent, or 2,230 more cases than during the same period last year, according to a Ministry of Health report, Xinhua News reports. “Among all the cases so far, only nine people were affected by hemorrhagic dengue fever, which is a more serious and sometimes mortal type of dengue, the report added,” the news service writes (9/17). Health authorities are urging people to eliminate possible sources of reproduction for mosquitoes, including disposing of old tires, according to a health ministry press release (9/11).

Dengue Vaccine Initiative Launches Redesigned Website, New Blog

The Global Network for Neglected Tropical Diseases’ “End the Neglect” blog reports that the Dengue Vaccine Initiative has launched a redesigned website, including a new blog that “will include regular posts about the disease, dengue in the news, the work of DVI and the development of a dengue vaccine” (9/17).

Sri Lankan Presidential Task Force Against Dengue Seeing Success

“Sri Lanka is making progress in the battle against mosquito-borne dengue fever, say health officials,” IRIN reports. According to the health ministry, 26,722 dengue cases were reported in 2011, down from 34,105 cases in 2010, and the number of dengue-related deaths dropped from 246 to 172, IRIN notes. Officials credit the establishment in May 2010 of an “anti-dengue Presidential Task Force — involving the ministries of health, defense, the environment, education, and local government, and headed by Sri Lankan President Mahinda Rajapaksa” — for the drop in cases, IRIN writes. The agencies worked together to launch widespread education campaigns, “clea[n] up areas suspected of being mosquito breeding grounds,” and impose fines for illegal dumping, according to the news agency (12/29).

More Than 40% Of World’s Population At Risk Of Dengue, WHO Fact Sheet States

“The incidence of dengue has grown dramatically around the world in recent decades,” the WHO writes in an updated fact sheet about dengue and severe dengue published on the organization’s website. According to the fact sheet, “Over 2.5 billion people — over 40 percent of the world’s population — are now at risk from dengue,” and “WHO currently estimates there may be 50-100 million dengue infections worldwide every year” (January 2012).

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