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New Study Lessens Concerns About Dengue Vaccine Production Costs

“Research funded by the Dengue Vaccine Initiative (DVI) involving an economic analysis of producing a tetravalent dengue vaccine shows that the cost could be as low as $0.20 per dose with an annual production level of 60 million doses packaged in 10-dose vials,” a Sabin Vaccine Institute press release reports. The study, published in the July 6 issue of the journal Vaccine, “used data on a vaccine developed by U.S. NIH and the facilities of the Instituto Butantan in Sao Paulo, Brazil,” the press release notes, adding the findings “should provide confidence to ministries of health that they can aggressively plan for the inclusion of dengue vaccine in their immunization programs, as the vaccine should be available at a cost that even middle-income and developing countries can afford” (6/27).

Magazine Examines Efforts To Biologically Alter Bugs To Fight Human Diseases

Pacific Standard magazine examines efforts by researchers around the globe to biologically modify bugs to fight human diseases, such as dengue fever. “Biologically altering bugs isn’t entirely new; it’s been done for nearly half a century to protect crops. … It’s only recently, however, that scientists have begun experimenting with using this technology to combat human diseases,” the magazine writes, adding, “If they succeed, they could create an entirely new way of stopping not only dengue but other insect-borne scourges, such as yellow fever, West Nile virus, and malaria. And stopping these diseases has never been more urgent.”

Dengue Fever Vaccine 'May Be In Sight,' Reuters Reports

Reuters reports on efforts to develop a vaccine for dengue fever, writing that “victory over … the intensely painful ‘breakbone fever’ … may be in sight.” Paris-based firm Sanofi “hopes for positive results in September from a key trial among children in Thailand that would set it on course to market a shot in 2015, which would prevent an estimated 100 million cases of dengue infection each year,” the news service writes, noting, “Of 20,000 annual deaths, many are of children.” According to Reuters, “Results from that clinical study, in what is known as the Phase IIb of the international standard three-stage process of assessment, are expected in the third quarter” and “will also be presented for scientific scrutiny at the annual meeting of the American Society of Tropical Medicine and Hygiene in Atlanta in November.”

Dengue Fever Costs Puerto Rico Nearly $38M A Year, Study Shows

“The costs of treating and coping with dengue fever in Puerto Rico total nearly $38 million a year, a new study,” published Wednesday in the American Journal of Tropical Medicine and Hygiene, finds, according to U.S. News & World Report. “It also said that every $1 spent on surveillance and prevention of the mosquito-borne disease could save $5 in illness-related costs,” the news service reports (5/2). “A team of researchers from Brandeis University says households in the U.S. territory pay almost half of that cost, with the government and insurance companies splitting the rest,” the Associated Press/Seattle Times notes (5/2).

Sri Lankan Presidential Task Force Against Dengue Seeing Success

“Sri Lanka is making progress in the battle against mosquito-borne dengue fever, say health officials,” IRIN reports. According to the health ministry, 26,722 dengue cases were reported in 2011, down from 34,105 cases in 2010, and the number of dengue-related deaths dropped from 246 to 172, IRIN notes. Officials credit the establishment in May 2010 of an “anti-dengue Presidential Task Force — involving the ministries of health, defense, the environment, education, and local government, and headed by Sri Lankan President Mahinda Rajapaksa” — for the drop in cases, IRIN writes. The agencies worked together to launch widespread education campaigns, “clea[n] up areas suspected of being mosquito breeding grounds,” and impose fines for illegal dumping, according to the news agency (12/29).

More Than 40% Of World’s Population At Risk Of Dengue, WHO Fact Sheet States

“The incidence of dengue has grown dramatically around the world in recent decades,” the WHO writes in an updated fact sheet about dengue and severe dengue published on the organization’s website. According to the fact sheet, “Over 2.5 billion people — over 40 percent of the world’s population — are now at risk from dengue,” and “WHO currently estimates there may be 50-100 million dengue infections worldwide every year” (January 2012).

Growing Number Of Dengue Cases In India Increases Risk Of Disease Spreading Worldwide, Experts Warn

“An epidemic of dengue fever in India is fostering a growing sense of alarm even as government officials here have publicly refused to acknowledge the scope of a problem that experts say is threatening hundreds of millions of people, not just in India but around the world,” the New York Times reports. Dengue is endemic in half of the world’s countries and continuing to spread, experts say, according to the newspaper. In India’s capital, New Delhi, “where areas of standing water contribute to the epidemic’s growth, hospitals are overrun and feverish patients are sharing beds and languishing in hallways,” the newspaper writes. With officials citing 30,002 cases of dengue in India through October, “a 59 percent jump from the 18,860 recorded for all of 2011,” several experts say the true number of infections in the country is in the tens of millions, the New York Times notes.

Sri Lankan Health Officials Report Increase In Number Of Dengue Cases In First Quarter Compared To 2011

Sri Lankan health authorities “have reported a three-fold increase in the number of recorded dengue fever cases in the first quarter of this year,” IRIN reports. According to the national Epidemiology Unit, “9,317 dengue cases and 38 deaths were reported in the first three months of 2012, [compared with] 3,103 in the first quarter of 2011,” the news service writes, noting that more than half of the cases were recorded “in the country’s Western Province, where most of the island’s 20 million inhabitants live.” Intermittent rain, which allows stagnant water to collect and create mosquito breeding grounds, are expected to continue through April, and “[h]ealth officials agree that removing mosquito breeding sites is the most important step in mitigating risk,” according to IRIN. “In May 2010 the government launched a campaign to curb the spread of the disease,” and last year the number of cases dropped when compared to 2010, the news service notes (4/11).

Experimental Dengue Vaccine Protects Against 3 Of 4 Viral Strains, Study Results Show

“The world’s first vaccine against dengue fever, being developed by French drugmaker Sanofi SA, protected against three of the virus’s four strains in a keenly awaited clinical trial in Thailand,” the company announced on Wednesday, Reuters reports (Hirschler/Regan, 7/25). “The vaccine actually generated antibody responses against all four strains of the virus, but for some reason, one strain was still able to infect children who received the vaccine, the company said, and scientists are now trying to figure out why,” the Los Angeles Times’ “Science Now” blog reports, adding, “Meanwhile, a much larger trial involving 31,000 adults and children is now under way in 10 countries in Asia and Latin America” (Maugh, 7/26). Reuters notes, “Other drug companies are also working on dengue vaccines but Sanofi’s product is several years ahead” (7/25).

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